Thermal and Melt Wear Characterization of Materials in Sliding Contact at High Speed Energy Sink

The Holloman High Speed Test Track is used to evaluate hypersonic aircraft materiel in a near-operational environment. The four-stage pusher rocket sled is capable of accelerating a test apparatus to hypersonic speeds in a matter of seconds. The sled must contend with tremendous thermal, mechanical, and aerodynamic loading during each run. The effects of the combination of forces acting on the sled are most acute at the interface between the rail and the wraparound slipper that holds the sled to the rail. Frictional heating due to sliding contact between the slipper and the rail coupled with mechanical wear can lead to significant material degradation in the slipper. Aerodynamic heating can exacerbate deleterious wear effects. This work considers the application of thermal and aerodynamic loading on the slipper. A two-dimensional finite element model is employed to depict temperature distribution and estimate melt wear over the course of a test run. The thermal load cases considered allow a new perspective on the slipper wear phenomena and should serve as a building block in future research endeavors

Subcritical route to turbulence via the Orr mechanism in a quasi-two-dimensional boundary layer

The link to the online abstract of this manuscript, accepted in Phys. Rev. Fluids, is https://journals.aps.org/prfluids/accepted/32074S4aH8b1c608e19768b42571f9001086a3f44. A subcritical route to turbulence via purely quasi-two-dimensional mechanisms, for a quasi-two-dimensional system composed of an isolated exponential boundary layer, is numerically investigated. Exponential boundary layers are highly stable, and are expected to form on the walls of liquid metal coolant ducts within magnetic confinement fusion reactors. Subcritical transitions were detected only at weakly subcritical Reynolds numbers (at most $\approx 70$% below critical). Furthermore, the likelihood of transition was very sensitive to both the perturbation structure and initial energy. Only the quasi-two-dimensional Tollmien-Schlichting wave disturbance, attained by either linear or nonlinear optimisation, was able to initiate the transition process, by means of the Orr mechanism. The lower initial energy bound sufficient to trigger transition was found to be independent of the domain length. However, longer domains were able to increase the upper energy bound, via the merging of repetitions of the Tollmien-Schlichting wave. This broadens the range of initial energies able to exhibit transitional behaviour. Although the eventual relaminarization of all turbulent states was observed, this was also greatly delayed in longer domains. The maximum nonlinear gains achieved were orders of magnitude larger than the maximum linear gains (with the same initial perturbations), regardless if the initial energy was above or below the lower energy bound. Nonlinearity provided a second stage of energy growth by an arching of the conventional Tollmien-Schlichting wave structure. A streamwise independent structure, able to efficiently store perturbation energy, also formed.Comment: 33 pages, 16 figures, accepted for publication in Phys. Rev. Fluids, https://journals.aps.org/prfluids/accepted/32074S4aH8b1c608e19768b42571f9001086a3f4

Subcritical transition to turbulence in quasi-two-dimensional shear flows

The transition to turbulence in ducts, pipes or other conduits is a crucial phenomenon. It determines the energy consumption and heat or mass exchange in countless processes: whether cooling circuits of heat exchangers, pipelines or chemical reactors to cite but a few. The transition occurs at relatively low flow rates as a response to perturbations exceeding a critical amplitude (such transitions are subcritical) through an intrinsically three-dimensional (3D) mechanism. However, fluid motion can be restricted to two dimensions, if it is stratified, subject to rapid rotation or intense magnetic fields, for example in rotating machines or in the liquid metal cooling circuits of nuclear fusion reactors. Subcritical turbulence has yet to be observed in 2D or quasi-2D flows, let alone a transition to it. Here we use stability analysis and direct numerical simulations on the example of a duct flow driven by the motion of its lateral walls to provide the first evidence of turbulence in subcritical quasi-2D shear flows. We further show that the scenario leading to turbulence mostly relies on the nonlinear dynamics of so-called Tollmien-Schlichting waves, rather than on perturbations experiencing fast, transient growth. Although the transition is subcritical, it cannot take place at such low flow rates as in 3D flows, because these waves are severly damped. This alternative scenario opens a new route to turbulence that calls for exploration. This new landscape may reset current strategies to promote or to hinder quasi-2D turbulence in practical applications, including in fusion reactors.Comment: Combined main paper (7 pages, 5 figures) and supplementary information (16 pages, 6 figures, 5 tables), submitted for consideration to Nature Physic

Using the Minimax Accelerometer to Quantify the Demands of Preseason Training in NCAA Volleyball: A Descriptive Case-Study Study

Abstract available in the 9th Annual Coaches and Sport Science College

Variation in Intraoperative and Postoperative Utilization for 3 Common General Surgery Procedures.

ObjectiveThe aim of this study was to understand variation in intraoperative and postoperative utilization for common general surgery procedures.Summary background dataReducing surgical costs is paramount to the viability of hospitals.MethodsRetrospective analysis of electronic health record data for 7762 operations from 2 health systems. Adult patients undergoing laparoscopic cholecystectomy, appendectomy, and inguinal/femoral hernia repair between November 1, 2013 and November 30, 2017 were reviewed for 3 utilization measures: intraoperative disposable supply costs, procedure time, and postoperative length of stay (LOS). Crossed hierarchical regression models were fit to understand case-mixed adjusted variation in utilization across surgeons and locations and to rank surgeons.ResultsThe number of surgeons performing each type of operation ranged from 20 to 63. The variation explained by surgeons ranged from 8.9% to 38.2% for supply costs, from 15.1% to 54.6% for procedure time, and from 1.3% to 7.0% for postoperative LOS. The variation explained by location ranged from 12.1% to 26.3% for supply costs, from 0.2% to 2.5% for procedure time, and from 0.0% to 31.8% for postoperative LOS. There was a positive correlation (ρ = 0.49, P = 0.03) between surgeons' higher supply costs and longer procedure times for hernia repair, but there was no correlation between other utilization measures for hernia repair and no correlation between any of the utilization measures for laparoscopic appendectomy or cholecystectomy.ConclusionsSurgeons are significant drivers of variation in surgical supply costs and procedure time, but much less so for postoperative LOS. Intraoperative and postoperative utilization profiles can be generated for individual surgeons and may be an important tool for reducing surgical costs

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients.

In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a broad range of stakeholders invested in the care of older adults to focus on the topic of cognitive health and aging. Summit participants specifically examined questions of who should be screened for cognitive impairment and how they should be screened in medical settings. This is important in the context of an acute illness given that the presence of cognitive impairment can have significant implications for care and for the management of concomitant diseases as well as pose a major risk factor for dementia. Participants arrived at general principles to guide future screening approaches in medical populations and identified knowledge gaps to direct future research. Key learning points of the summit included: recognizing the importance of educating patients and healthcare providers about the value of assessing current and baseline cognition;emphasizing that any screening tool must be appropriately normalized and validated in the population in which it is used to obtain accurate information, including considerations of language, cultural factors, and education; andrecognizing the great potential, with appropriate caveats, of electronic health records to augment cognitive screening and tracking of changes in cognitive health over time

The behavior of iron and zinc stable isotopes accompanying the subduction of mafic oceanic crust: A case study from Western Alpine ophiolites

Arc lavas display elevated Fe3+/ΣFe ratios relative to MORB. One mechanism to explain this is the mobilization and transfer of oxidized or oxidizing components from the subducting slab to the mantle wedge. Here we use iron and zinc isotopes, which are fractionated upon complexation by sulfide, chloride, and carbonate ligands, to remark on the chemistry and oxidation state of fluids released during prograde metamorphism of subducted oceanic crust. We present data for metagabbros and metabasalts from the Chenaillet massif, Queyras complex, and the Zermatt-Saas ophiolite (Western European Alps), which have been metamorphosed at typical subduction zone P-T conditions and preserve their prograde metamorphic history. There is no systematic, detectable fractionation of either Fe or Zn isotopes across metamorphic facies, rather the isotope composition of the eclogites overlaps with published data for MORB. The lack of resolvable Fe isotope fractionation with increasing prograde metamorphism likely reflects the mass balance of the system, and in this scenario Fe mobility is not traceable with Fe isotopes. Given that Zn isotopes are fractionated by S-bearing and C-bearing fluids, this suggests that relatively small amounts of Zn are mobilized from the mafic lithologies in within these types of dehydration fluids. Conversely, metagabbros from the Queyras that are in proximity to metasediments display a significant Fe isotope fractionation. The covariation of δ56Fe of these samples with selected fluid mobile elements suggests the infiltration of sediment derived fluids with an isotopically light signature during subduction

Conformation and dynamics of human urotensin II and urotensin related peptide in aqueous solution

Conformation and dynamics of the vasoconstrictive peptides human urotensin II (UII) and urotensin related peptide (URP) have been investigated by both unrestrained and enhanced-sampling molecular-dynamics (MD) simulations and NMR spectroscopy. These peptides are natural ligands of the G-protein coupled urotensin II receptor (UTR) and have been linked to mammalian pathophysiology. UII and URP cannot be characterized by a single structure but exist as an equilibrium of two main classes of ring conformations, <i>open</i> and <i>folded</i>, with rapidly interchanging subtypes. The <i>open</i> states are characterized by turns of various types centered at K⁸Y⁹ or F⁶W⁷ predominantly with no or only sparsely populated transannular hydrogen bonds. The <i>folded</i> conformations show multiple turns stabilized by highly populated transannular hydrogen bonds comprising centers F⁶W⁷K⁸ or W⁷K⁸Y⁹. Some of these conformations have not been characterized previously. The equilibrium populations that are experimentally difficult to access were estimated by replica-exchange MD simulations and validated by comparison of experimental NMR data with chemical shifts calculated with density-functional theory. UII exhibits approximately 72% <i>open</i>:28% <i>folded</i> conformations in aqueous solution. URP shows very similar ring conformations as UII but differs in an <i>open:folded</i> equilibrium shifted further toward <i>open</i> conformations (86:14) possibly arising from the absence of folded N-terminal tail-ring interaction. The results suggest that the different biological effects of UII and URP are not caused by differences in ring conformations but rather by different interactions with UTR

Multivariate Cutoff Level Analysis (MultiCoLA) of large community data sets

High-throughput sequencing techniques are becoming attractive to molecular biologists and ecologists as they provide a time- and cost-effective way to explore diversity patterns in environmental samples at an unprecedented resolution. An issue common to many studies is the definition of what fractions of a data set should be considered as rare or dominant. Yet this question has neither been satisfactorily addressed, nor is the impact of such definition on data set structure and interpretation been fully evaluated. Here we propose a strategy, MultiCoLA (Multivariate Cutoff Level Analysis), to systematically assess the impact of various abundance or rarity cutoff levels on the resulting data set structure and on the consistency of the further ecological interpretation. We applied MultiCoLA to a 454 massively parallel tag sequencing data set of V6 ribosomal sequences from marine microbes in temperate coastal sands. Consistent ecological patterns were maintained after removing up to 35–40% rare sequences and similar patterns of beta diversity were observed after denoising the data set by using a preclustering algorithm of 454 flowgrams. This example validates the importance of exploring the impact of the definition of rarity in large community data sets. Future applications can be foreseen for data sets from different types of habitats, e.g. other marine environments, soil and human microbiota